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Decitabine

  • Decitabine 200x200
  • Decitabine 600x600
Price:
$109.00
Catalog #:
C3324-10
Quantity:


Product Description

Decitabine is a cytosine nucleoside analog that acts as a potent inhibitor of DNA methylation. Decitabine can be incorporated into DNA and inhibits further DNA methylation and induce apoptosis and senescence in leukemic cells. [1]

In a panel of primary (acute myeloid leukemia) AML cultures, Decitabine significantly inhibited proliferation and reduced cell viability with IC50 10-60 nM. [2]

Decitabine shows activity in a broad range of hematologic disorders. Currently, Decitabine is being studied in a Phase III clinical trials in patients with myelodysplastic syndrome (MDS) [3] and in a Phase II clinical trials in patients with AML [4].


Technical information:

Chemical Formula:   C8H12N4O4
CAS #:   2353-33-5
Molecular Weight:   228.21
Purity:   > 98%
Appearance:   White
Chemical Name:   4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one
Solubility:   Up to 100 mM in DMSO
Synonyms:   Decitabine, Deoxycytidine, 5-Aza-2?-deoxycytidine

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


Reference:

1. Decitabine is a cytosine nucleoside analog that acts as a potent inhibitor of DNA methylation. Decitabine can be incorporated into DNA and inhibits further DNA methylation and induce apoptosis and senescence in leukemic cells. [1] In a panel of primary (acute myeloid leukemia) AML cultures, Decitabine significantly inhibited proliferation and reduced cell viability with IC50 10-60 nM. [2] Decitabine shows activity in a broad range of hematologic disorders.Decitabine has been approved for treatment of myelodysplastic syndrome (MDS) [3] and is in a Phase II clinical trial in patients with acute myelogenous leukemia (AML). [4] Pubmed ID: 21044612
2. Leonard SM, et al. Sequential treatment with cytarabine and decitabine has an increased anti-leukemia effect compared to cytarabine alone in xenograft models of childhood acute myeloid leukemia. PLoS One. 2014; 9(1):e87475 Pubmed ID: 24489920
3. Decitabine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia. clinicaltrials.gov/NCT00049582
4. An Efficacy and Safety Study of Decitabine (DACOGEN) Plus Talacotuzumab (JNJ-56022473; Anti CD123) Versus Decitabine (DACOGEN) Alone in Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy. clinicaltrials.gov/NCT02472145

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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