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Mocetinostat (MGCD0103)

  • Mocetinostat 200x200
  • Mocetinostat 600-600
Price:
$169.00
Catalog #:
C6623-5
Quantity:


Product Description

Mocetinostat (MGCD0103) is a potent and isotype-selective inhibitor of histone deacetylases (HDACs). In cell-free assays, Mocetinostat (MGCD0103) exhibited most potent inhibition against human HDAC1 (IC50 = 0.15 ?M) and also has inhibitory activity against HDAC2, HDAC3, and HDAC11, with IC50 values ranged 0.3 to 1.7 ?M. No activity was showed on HDACs 4-8. [1] Mocetinostat (MGCD0103) exhibited potent inhibition activity in proliferation of human cancer cell lines, both in cell-based assay and in human tumor xenografts in nude mice. [1]
Mocetinostat (MGCD0103) has been evaluated in Phase II clinical trials in patients with metastatic leiomyosarcoma [2] and HodgkinÂ’s lymphoma [3]."


Technical information:

Chemical Formula:   C23H20N6O
CAS #:   726169-73-9
Molecular Weight:   396.44
Purity:   > 98%
Appearance:   Off-white
Chemical Name:   N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide
Solubility:   Up to 10 mM in DMSO
Synonyms:   Mocetinostat, MGCD0103, MG0103

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


Reference:

1. Fournel M, et al. MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther. 2008; 7(4):759-68 Pubmed ID: 18413790
2.

SARC018: A Study of Mocetinostat and Gemcitabine in Patients With Metastatic Leiomyosarcoma. clinicaltrials.gov/NCT02303262 

3. Mocetinostat (MGCD0103) Plus Brentuximab Vedotin (SGN-35) in Patients With Relapsed or Refractory Hodgkin Lymphoma. clinicaltrials.gov/NCT02429375 

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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