Temozolomide is an highly orally-available, imidazotetrazine-based, monofunctional DNA alkylating agent. In vivo it spontaneously degrades and reacts with water to release a methyldiazonium cation which preferentially methylates DNA at N7 positions of guanine in guanine rich regions. The active agent also methylates N3 adenine and O6 guanine. [1]

Temozolomide, which enters the cerebrospinal fluid and does not require hepatic metabolism, demonstrates schedule-dependent antitumor activity against highly-resistant gliomas. [2] In Phase 1 clinical studies, temozolomide showed 100% p.o. bioavailability.

In L-1210 leukemia cells, temozolomide caused a dose-dependent accumulation of cells in the SL-G2-M phase. [3]

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.