Loading... Please wait...

Our Newsletter


AGI-5198 (IDH-C35) | IDH1 inhibitor

  • AGI-5198 (IDH-C35) (.png)
  • AGI-5198 (IDH-C35) (.jpg)
Price:
$169.00
Catalog #:
C2519-5
Quantity:


Product Description

AGI-5198 (IDH-C35) is a potent and selective isocitrate dehydrogenase 1 (IDH1) inhibitor specifically against R132H/C mutants (mIDH1) with IC50 at 100 nM range. AGI-5198 does not inhibit wild-type IDH1 or any of the examined IDH2 isoforms (IC50 > 100 µM).[1] AGI-5198 inhibits R-2-hydroxyglutarate (R-2HG) production by mIDH1. AGI-5198 also induces demethylation of histone H3K9me3 and expression of genes associated with gliogenic differentiation.

In both in vitro and in vivo studies, AGI-5198 inhibited the growth of glioma cells carrying mutated but not wild type IDH1, yet with no appreciable changes in genome-wide DNA methylation. These data suggest that mIDH1 may promote glioma growth through mechanisms beyond its well-characterized epigenetic effects. AGI-5198 could serve as a very useful chemical tool to probe the mechanism and treatment of mIDH1-carrying tumors


Technical information:

Chemical Formula:   C27H31FN4O2
CAS #:   1355326-35-0
Molecular Weight:   462.56
Purity:   > 98%
Appearance:   White
Chemical Name:   N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide
Solubility:   Up to 25 mM in DMSO
Synonyms:   AGI-5198, AGI5198, IDH-C35

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


Reference:

1. Rohle D, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013; 340(6132):626-30. Pubmed ID: 23558169

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.




Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the AGI-5198 (IDH-C35) | IDH1 inhibitor to your wish list.

You Recently Viewed...



Online Payments