Loading... Please wait...

Categories

Our Newsletter


BMS-207147 (Ravuconazole) | antifungal compound

  • BMS-207147 (Ravuconazole).jpg
  • BMS-207147 (Ravuconazole), 400x400px, png
Price:
$159.00
Catalog #:
C2207-5
Quantity:


Product Description

BMS207147 is a orally-available, triazole-based antifungal with MICs 2- to 4-fold more potent than itraconazole and 40-fold more active than fluconazole against yeasts. In all but 9 of 116 Candida strains tested, BMS207147 had MICs of < 0.5 ug/mL. [1]  In oral mouse studies, BMS207147 was shown to have a 3-fold longer half-life than itraconazole. [2] 

In 541 clinical isolates of Cryptococcus neoformans, BMS207147 again proved to be more potent than itraconazole and fluconazole (0.25 ug/mL vs 0.5 ug/mL and 8 ug/mL). [3]


Technical information:

Chemical Formula:   C22H17F2N5OS
CAS #:   182760-06-1
Molecular Weight:   437.47
Purity:   > 98%
Appearance:   White
Chemical Name:   4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
Solubility:   Up to 22 mM in DMSO
Synonyms:   BMS-207147, BMS 207147, BMS207147, Ravuconazole, ER-30346

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Fung-Tomc et al., In vitro activity of a new oral triazole, BMS-207147 (ER-30346). Antimicrob. Agents Chemother. 1998, 42(2), 313-318. Pubmed ID: 9527778
2. Yamazumi et al., In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America. Antimicrob. Agents Chemother. 1999, 43(9), 2236-2239. Pubmed ID: 10471571
3. Yamazumi et al., In vitro activities of ravuconazole (BMS-207147) against 541 clinical isolates of Cryptococcus neoformans. Antimicrob. Agents Chemother. 2000, 44(10), 2883-2886. Pubmed ID: 10991880

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Find Similar Products by Category

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the BMS-207147 (Ravuconazole) | antifungal compound to your wish list.

You Recently Viewed...