Hh-Ag1.5 is a small-molecule chemical agonist of Smoothened (Smo) receptor and is an activator of sonic hedgehog (Shh) signaling. It is derived from an initial synthetic hit compound "Hh-Ag1.1", and optimized to achieve the activity IC50 = 1 nM for agonist activity.
|Solubility:||Up to 50 mM in DMSO|
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
|1.||The Hedgehog Signaling Pathway as a Target for Anticancer Drug Discovery. Borzillo and Lippa. Current Topics in Medicinal Chemistry 2005, (5), 147-157.|
|2.||Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. Frank-Kamenetsky et. al. Journal of Biology 2002 (1): 10.2-10.19.|