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ITD-1 | TGF-β pathway inhibitor

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Price:
$169.00
Catalog #:
C4830-2s
Quantity:


Product Description

ITD-1 is a novel selective TGF-β pathway-selective inhibitor that inhibits TGF-β activity by selectively degrading the TGF-β2 receptor at the proteosome level. ITD-1 does not block the closely related Activin A signaling pathway. ITD-1 stimulates embryonic stem cells to differentiate into cardiomyocytes (IC50 0.4-0.8 µM) by degrading the receptor and inhibiting intracellular signaling. ITD-1 has been formulated as a salt to increase stability and improve water solubility (~0.1 mg/mL) for ease of handling. As a salt, ITD-1 is chemically and metabolically stable and is non-cytotoxic. ITD-1 can be used to study a wide range of biological questions in cellular processing and TGF-β signaling.


Technical information:

Chemical Formula:   C27H29NO3
CAS #:   N/A
Molecular Weight:   415.52
Purity:   >98%
Appearance:   Yellow solid
Chemical Name:   ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Willems E, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012;11(2):242-52. PMID: 22862949

Other Information:

Product Specification (pdf)
MSDS (pdf)

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