LDN-57444 is a specific inhibitor (Ki = 0.4 ?M) against Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), a member of deubiquitinating enzymes (DUBs). LDN-57444 increased proliferation of SH-SY5Y cells, a UCH-L1-expressing neuroblastoma line. 
As expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors, LDN-57444 is a useful tool for studying the roles of UCH-L1 in Alzheimers disease, Parkinsons disease, and other neurological disorders. [2,3]
|Chemical Name:||1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)|
|Solubility:||Up to 25 mM in DMSO|
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.
|1.||Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol. 2003; 10(9):837-46. Pubmed ID: 14522054|
|2.||Cartier AE, et al. Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J Neurosci. 2009; 29(24):7857-68. Pubmed ID: 19535597|
|3.||Zhang M, et al. Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1. J Neurochem. 2012; 120(6):1129-38. Pubmed ID: 22212137|