Necrostatin-1 is a specific ATP-competitive allosteric inhibitor (EC50 = 180 nM) of death domain receptor-associated adaptor kinase (RIP1)¹. It selectively blocks a specific programmed cell death pathway, necroptosis, which leads to necrosis. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade. Necrostatin-1 inhibits the necrosis-induced RIP1 and RIP3 interactions in vitro² and reduces ischemic brain injury in a mouse model of stroke³.

Technical information:

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

Reference:

Other Information:

Product Specification (pdf)
MSDS (pdf)