The compound StemRegenin 1 (SR1) is a selective, cell permeable, small molecule that promotes the self-renewal of human hematopoietic stem cells in culture. SR1 is an antagonist of the aryl hydrocarbon receptor.
SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. SR1 can be potentially used for ex vivo expansion of normal HSCs or leukemic stem/progenitor cells.
Technical information:
| Chemical Formula: | C24H23N5OS | |
| CAS #: | 1227633-49-9 | |
| Molecular Weight: | 429.54 | |
| Purity: | >98% | |
| Appearance: | White solid | |
| Chemical Name: | 4-(2-((2-(benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol | |
| Solubility: | Up to 35 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Anthony E. Boitano et al. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. Science 10 September 2010: 1345-1348. |
| 2. | Smith G.H. et al. Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism. J Phar Exp Therap. 338 2011: 318-327 |
Other Information:
Product Specification (pdf)
MSDS (pdf)
