Loading... Please wait...

Categories

Our Newsletter


R406 | SYK inhibitor

R406.jpg
  • R406.jpg
  • R406, 400x400px, png
Price:
$129.00
Catalog #:
C7406-2s
Quantity:
Buy in bulk and save

For larger amounts,
please Email us for a quote.

Product Description

R406 is an orally available small molecule targeting spleen tyrosine kinase (SYK) inhibitor with IC50 ~40 nM. It can block Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 has shown efficacy in a number of animal models of immune disorders. R406’s pro-drug R788 (Fostamatinib) is currently in phase III clinical trials to treat rheumatoid arthritis.

Technical information:

Chemical Formula:   C22H23FN6O5
CAS #:   841290-80-0
Molecular Weight:   470.45
Purity:   >98%
Appearance:   Gray solid
Chemical Name:   6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Solubility:   Up to 20 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.

Reference:

1. Braselmann S., et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006; 319(3):998-1008.
2. Sweeny DJ, Li W, Grossbard E, Lau DT. Contribution of gut bacteria to the metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey. Xenobiotica. 2010;40(6):415-23.

Other Information:

Product Specification (pdf)
MSDS (pdf)

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the R406 | SYK inhibitor to your wish list.

You Recently Viewed...