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SB-431542 is a selective and potent inhibitor of activin receptor-like kinase (ALK, the TGF-β type I receptor), specifically ALK4, ALK5 (IC50 = 94 nM) and ALK7. It has no effect on the other, more divergent ALK family members that recognize bone morphogenetic proteins (BMPs) such as ALK2, ALK3 or ALK6. It has also no effect on components of the ERK, JNK, or p38 MAP kinase pathways or on components of the signaling. SB431542 specifically blocks Smad signaling and suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes differentiation. SB431542 could enhance reprogramming efficiency when using it with MEK inhibitor PD0325901.
|Appearance:||Off white solid|
|Solubility:||Up to 100 mM in DMSO|
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
|1.||Tongxiang Lin, et al. A chemical platform for improved induction of human iPSCs. Nature Methods 6, 805 - 808 (2009).|
|2.||Laping NJ, et al. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol. 2002; 62(1):58-64.|
|3.||Inman GJ, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I|