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StemRegenin 1 (SR1) | Promote CD34+ cell expansion

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Price:
$159.00
Catalog #:
C7710-1s
Quantity:


Product Description

The compound StemRegenin 1 (SR1) is a selective, cell permeable, small molecule that promotes the self-renewal of human hematopoietic stem cells in culture. SR1 is an antagonist of the aryl hydrocarbon receptor.

SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. SR1 can be potentially used for ex vivo expansion of normal HSCs or leukemic stem/progenitor cells.

Product Citation


Technical information:

Chemical Formula:   C24H23N5OS
CAS #:   1227633-49-9
Molecular Weight:   429.54
Purity:   >98%
Appearance:   White solid
Chemical Name:   4-(2-((2-(benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol
Solubility:   Up to 35 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Anthony E. Boitano et al. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. Science 10 September 2010: 1345-1348.
2. Smith G.H. et al. Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism. J Phar Exp Therap. 338 2011: 318-327

Other Information:

Product Specification (pdf)
MSDS (pdf)

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