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The compound StemRegenin 1 (SR1) is a selective, cell permeable, small molecule that promotes the self-renewal of human hematopoietic stem cells in culture. SR1 is an antagonist of the aryl hydrocarbon receptor.
SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. SR1 can be potentially used for ex vivo expansion of normal HSCs or leukemic stem/progenitor cells.
|Solubility:||Up to 35 mM in DMSO|
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
|1.||Anthony E. Boitano et al. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. Science 10 September 2010: 1345-1348.|
|2.||Smith G.H. et al. Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism. J Phar Exp Therap. 338 2011: 318-327|