Loading... Please wait...

Our Newsletter


Y-27632 | ROCK inhibitor

  • Y-27632.jpg
  • Y-27632, 400x400px, png
Price:
$109.00
Catalog #:
C9127-2s
Quantity:


Product Description

Y-27632 is widely used as a specific inhibitor of the Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family. It has been found to prevent dissociation-induced apoptosis in human embryonic stem cells and enhance the survival and cloning efficiency of dissociated hES cells without affecting their self-renewal properties or pluripotency. Y-27632 can also enhance survival during the transplantation of ES cell-derived neural precursors.


Technical information:

Chemical Formula:   C14H21N3O·2HCl
CAS #:   146986-50-7
Molecular Weight:   329.27
Purity:   >98%
Appearance:   White solid
Chemical Name:   (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Ishizaki, T. et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol (2000) 57: 976-983.
2. Koyanagi et al. Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J. Neurosci Res (2008) 86: 270-280.
3. Watanabe et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotech (2007) 25: 681-686.

Other Information:

Product Specification (pdf)
MSDS (pdf)

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the Y-27632 | ROCK inhibitor to your wish list.

You Recently Viewed...



Online Payments