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YM155 | Survivin inhibitor

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Price:
$79.00
Catalog #:
C9615-5
Quantity:


Product Description

YM155 is an imidazolium-based inhibitor of survivin in a dose-dependent manner when administered from 10 to 1000 nM. YM155 suppresses survivin expression and induces apoptosis in PC-3 and PPC-1 human hormone-refractory prostate cancer (HRPC) cell lines at 10 nM. In addition to other HRPC cell lines, YM155 also shows activity against malignant melanoma lines SKMEL5 and A375 at GI50s of 4.2 and 6.3 nM, respectively. [1]

In independent studies, YM155 was shown to inhibit SK-NEP-1 Wilms tumor cells at an IC50 of 100 nM, while concurrently inducing apoptosis. [2]

YM155 is believed to sensitize NSCLC cells to radiation both in vivo and in vitro by downregulating survivin expression in a concentration- and time-dependent manner. YM155 delays the repair of radaiation-induced double-strand breaks in nuclear DNA. [3]


Technical information:

Chemical Formula:   C20H19BrN4O3
CAS #:   781661-94-7
Molecular Weight:   443.29
Purity: > 98%
Appearance:   White
Chemical Name:   1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1)
Solubility:   Up to 100 mM in DMSO
Synonyms:   YM155, YM-155

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Nakahara et al., YM155, a Novel Small-Molecule Survivin Suppressant, Induces Regression of Established Human Hormone-Refractory Prostate Tumor Xenografts. Cancer Res. 2007, 67, 8014-8021. Pubmed ID: 17804712
2. Tao et al., Survivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells. BMC Cancer, 2012, 12, 619-631. Pubmed ID: 23267699
3. Iwasa et al., Radiosensitizing Effect ofYM155, a Novel Small-Molecule Survivin Suppressant, in Non^Small Cell Lung Cancer Cell Lines. Clin. Cancer Res. 2008, 14, 6496-6504.

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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