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Zearalenone (Toxin F2) | ER agonist

  • Zearalenone (Toxin-F2) (.png)
  • Zearalenone (Toxin-F2) (.jpg)
Price:
$69.00
Catalog #:
C9327-10
Quantity:


Product Description

Zearalenone is a heat-resistant mycotoxin produced by fungi in food and animal feeds [1]. It acts as an estrogen receptor agonist and can cause hormonal effects in animal species such as the pig [2]. Evidence for Zearalenone effects have been observed in a wide variety of animals. The association between Zearalenone exposure and human diseases remains speculative at present; it has been considered as a possible causative agent in outbreaks of precocious pubertal changes in young children and has been suggested to have a possible involvement in human cervical cancer. [3,4]


Technical information:

Chemical Formula:   C18H22O5
CAS #:   17924-93-4
Molecular Weight:   318.36
Purity:   > 98%
Appearance:   Off-white
Chemical Name:   (3S,?11E)-?3,?4,?5,?6,?9,?10-?hexahydro-?14,?16-?dihydroxy-?3-?methyl-?1H-?2-?benzoxacyclotetradecin-?1,?7(8H)-?dione
Solubility:   Up to 50 mM in DMSO
Synonyms:   Zearalenone, Mycotoxin F2, FES, Zenone, Toxin F2

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


Reference:

1. Zinedine A, et al. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxin. Food Chem Toxicol, 2007; 45:1-18 Pubmed ID: 17045381
2. Tiemann U. and Dänicke S. In vivo and in vitro effects of the mycotoxins zearalenone and deoxynivalenol on different non-reproductive and reproductive organs in female pigs: A review.Food Addit Contam, 2007; 24:306-314 Pubmed ID: 17364934
3. Caloni F. and Cortinovis C. Effects of fusariotoxins in the equine species. Vet J, 2010; 186:157-161 Pubmed ID: 19837621
4. Massart F. and Saggese G. Oestrogenic mycotoxin exposures and precocious pubertal development. Int J Androl, 2010; 33:369-376 Pubmed ID: 17364934

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.







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