Loading... Please wait...

Our Newsletter


BMS-477118 (Saxagliptin) | DPP-IV inhibitor

  • BMS-477118 (Saxagliptin).jpg
  • BMS-477118 (Saxagliptin), 400x400px, png
Price:
$189.00
Catalog #:
C2477-5
Quantity:


Product Description

Saxagliptin is an orally-available, adamantyl-based, reversible inhibitor of DPP-IV for the treatment of Type 2 diabetes with an IC50 of 26 nM and Ki of 0.6-1.3 nM [1, 2]. Saxagliptin is more selective than other approved DPP-IV inhibitors (vildagliptin, sitagliptin) and is 400-fold and 75-fold selective over DPP-VIII and DPP-IX, respectively. [1] Once-daily administration of saxagliptin either as a monotherapy or in combination results in a significant reductions in fasting and postprandial plasma glucose and HbA1c.

Saxagliptin reduces the degradation of the incretin hormone glucagon-like peptide-1, improving b-cell function and suppression of glucagon secretion. [2]


Technical information:

Chemical Formula:   C18H25N3O2
CAS #:   361442-04-8
Molecular Weight:   315.41
Purity:   >98%
Appearance:   White
Chemical Name:   (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl) acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
Solubility:   Up to 22 mM in DMSO
Synonyms:   BMS-477118, BMS 477118, BMS477118, Saxagliptin, Onglyza

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Tahrani et al., Saxagliptin: a new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus. Adv. Ther. 2009, 26(3), 249-262. Pubmed ID: 19330494
2. Deacon et al., Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Adv. Ther. 2009, 26(5), 488-499. Pubmed ID: 19444391

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the BMS-477118 (Saxagliptin) | DPP-IV inhibitor to your wish list.

You Recently Viewed...