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CGS-21680 | A2A receptor agonist

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Catalog #:

Product Description

CGS21680, an A2A adenosine receptor agonist, is under investigation in various inflammation models for potential novel therapies. For example, CGS21680 possesses an anti-inflammatory effect during chronic inflammation and lessens the tissue damage associated with collagen-induced arthritis. [1]

CGS21680 reduces spinal cord injury-induced phosphorylation of JNK and MAPK. It was shown also to reduce the influx of MPO-positive leukocytes, NFkB activation, and iNOS expression. Additionally, CGS21680 reduced phosphorylation of p65 on Ser536. [2]

In acute lung inflammation models, CGS21680 was shown to reduce neutrophil infiltration and thus degree of lung injury after a carrageenan-challenge. [3]

Technical information:

Chemical Formula:   C23H29N7O6
CAS #:   124182-57-6
Molecular Weight:   499.52
Purity:   > 98%
Appearance:   White
Chemical Name:   3-[4-[2-[ [6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid
Solubility:   Up to 100 mM in DMSO
Synonyms:   CGS-21680, CGS 21680, CGS21680

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Mazzon et al., CGS 21680, an agonist of the adenosine (A2A) receptor, reduces progression of murine type II collagen-induced arthritis. J. Rheumatol., 2011, 38(10), 2119-2129. Pubmed ID: 21765105
2. Genovese, The selective adenosine A2A receptor agonist CGS 21680 reduces JNK MAPK activation in oligodendrocytes in injured spinal cord. Shock, 2009, 32(6), 578-585. Pubmed ID: 19295488
3. Impellizzeri et al., CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation. Eur. J. Pharmacol. 2011, 668, 305-316. Pubmed ID: 21756897

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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