Loading... Please wait...

Categories

Our Newsletter


CGS-21680 | A2A receptor agonist

  • CGS-21680.jpg
  • CGS-21680, 400x400px, png
Price:
$129.00
Catalog #:
C2216-5
Quantity:


Product Description

CGS21680, an A2A adenosine receptor agonist, is under investigation in various inflammation models for potential novel therapies. For example, CGS21680 possesses an anti-inflammatory effect during chronic inflammation and lessens the tissue damage associated with collagen-induced arthritis. [1]

CGS21680 reduces spinal cord injury-induced phosphorylation of JNK and MAPK. It was shown also to reduce the influx of MPO-positive leukocytes, NFkB activation, and iNOS expression. Additionally, CGS21680 reduced phosphorylation of p65 on Ser536. [2]

In acute lung inflammation models, CGS21680 was shown to reduce neutrophil infiltration and thus degree of lung injury after a carrageenan-challenge. [3]


Technical information:

Chemical Formula:   C23H29N7O6
CAS #:   124182-57-6
Molecular Weight:   499.52
Purity:   > 98%
Appearance:   White
Chemical Name:   3-[4-[2-[ [6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid
Solubility:   Up to 100 mM in DMSO
Synonyms:   CGS-21680, CGS 21680, CGS21680

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Mazzon et al., CGS 21680, an agonist of the adenosine (A2A) receptor, reduces progression of murine type II collagen-induced arthritis. J. Rheumatol., 2011, 38(10), 2119-2129. Pubmed ID: 21765105
2. Genovese, The selective adenosine A2A receptor agonist CGS 21680 reduces JNK MAPK activation in oligodendrocytes in injured spinal cord. Shock, 2009, 32(6), 578-585. Pubmed ID: 19295488
3. Impellizzeri et al., CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation. Eur. J. Pharmacol. 2011, 668, 305-316. Pubmed ID: 21756897

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Find Similar Products by Category

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the CGS-21680 | A2A receptor agonist to your wish list.

You Recently Viewed...