Loading... Please wait...

Our Newsletter

Foretinib (GSK1363089)

  • Foretinib 200x200
  • Foretinib 600x600
Catalog #:

Product Description

Foretinib (GSK1363089) is a potent multi-kinase inhibitor of HGFR, VEGFR, KIT, Flt, PDGFR and Tie-2. In a cell-free assay, Foretinib (GSK1363089) is most potent for Met, KDR, and Tie-2, with IC50 values of 0.4 nM, 0.86 nM, and 1.1 nM, respectively. Foretinib (GSK1363089) also inhibits Ron, Flt1/3/4, KIT, and PDGFR?/?, with higher IC50 values ranging from 3 nM to 9.6 nM. [1] It binds tightly to Met and KDR with a very slow off-rate and inhibits tumor formation in an in vivo murine model of lung metastasis. [1]
A recent report showed that Foretinib (GSK1363089), by targeting cMet, significantly reduced primary medulloblastoma growth and invasion, and increased survival in disseminated mouse models of sonic hedgehog (SHH)-driven medulloblastoma. [2]
Foretinib (GSK1363089) has been examined in multiple clinical trials in wild-range of cancer patients including metastatic breast cancer, metastatic gastric cancer, papillary renal cell carcinoma (PRC), liver cancer, non-small-cell lung cancer, and squamous cell cancer of the head and neck."

Technical information:

Chemical Formula:   C34H34F2N4O6
CAS #:   849217-64-7
Molecular Weight:   632.65
Purity:   > 98%
Appearance:   White
Chemical Name:   N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Solubility:   Up to 100 mM in DMSO
Synonyms:   Foretinib, GSK1363089,GSK 1363089, EXEL-2880, XL-880

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


1. Qian F, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 2009; 69(20):8009-16 Pubmed ID: 19808973
2. Faria CC, et al. Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma. Cancer Res. 2015; 75(1):134-46 Pubmed ID: 25391241
3. Study of Foretinib in Combination With Lapatinib in Patients With Metastatic Breast Cancer. clinicaltrials.gov/NCT01138384

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the Foretinib (GSK1363089) to your wish list.

You Recently Viewed...