Loading... Please wait...

Our Newsletter

KU-55933 | ATM kinase inhibitor

  • KU-55933.jpg
  • KU-55933, 400x400px, png
Catalog #:

Product Description

KU55933 is an ATP-competitive, thioanthrene-pyranone-based inhibitor of ATM kinase with an IC50 of 13 nM and Ki of 2.2 nM and >100-fold selectivity over PI3K related kinases. [1] KU55933 inhibits cell proliferation by inducing G1 cell cycle arrest by downregulation of cyclin D1 synthesis in MDA-MB-453 breast cancer cells and PC-3 prostate cancer cells. [2] KU55933 inhibits insulin- and IGF1-stimulated Akt phosphorylation at both Ser473 and Thr308. [2] ATM cellular inhibition by KU55933 was demonstrated in additional phosphorylation targets, including p53 Ser15, H2AX Ser139, NBS1 Ser343, Chk1 Ser345, and SMC1 Ser966. [1]

KU55933 is being studied as a radiosensitizer, having been shown to sensitize HeLa cells to the effects of topoisomerase inhibitors, etoposide, doxorubicin, amsacrine, and camptothecin. [1] When in combination with rapamycin, KU55933 induces apoptosis and arrests any induced feedback activation of Akt. [2]

Technical information:

Chemical Formula:   C21H17NO3S2
CAS #:   587871-26-9
Molecular Weight:   395.49
Purity:   > 98%
Appearance:   White
Chemical Name:   2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
Solubility:   Up to 100 mM in DMSO
Synonyms:   KU-55933, KU 55933, KU55933

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Hickson et al., Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004, 64(24), 9152-9159. Pubmed ID: 15604286
2. Li et al., The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt. Mol. Cancer. Ther. 2010, 9(1), 113-125. Pubmed ID: 20053781

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the KU-55933 | ATM kinase inhibitor to your wish list.

You Recently Viewed...