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MG132 | Proteasome inhibitor

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Catalog #:

Product Description

MG-132 is a triterpene, peptide-aldehyde proteasome inhibitor derived from a Chinese medicinal plant. It inhibits 20S proteasome activty by covalently binding to the active site of the beta subunits and effectively blocks the proteolytic activity of the 26S proteasome complex. Through the formation of reactive oxygen species, MG-132 inhibits tumor cell growth by inducing cell cycle arrest and triggering apoptosis. [1]

MG-132 was found to enhance IL-6 expression in HUVEC. MG-132 does not affect IkB levels, suggesting that proteasome inhibition does not influence the NF-kB system without any agonist stimulation. In similar studies, MG-132 is believed to inhibit the degradation of phosphorylated MEK1/2 and activate the downstream region of this signalling cascade. [2]

In NCIH2452 and NCI H2052 human thoracic malignant pleural mesothelioma (MPM) cell lines, it was foud that 0.5 uM concentrations of MG-132 caused significant apoptosis as evidenced by DNA damage, cleavage of PARP and caspases 3, 7, and 9. [3]

Technical information:

Chemical Formula:   C26H41N3O5
CAS #:   133407-82-6
Molecular Weight:   475.62
Purity:   >98%
Appearance:   White
Chemical Name:   benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate
Solubility:   Up to 100 mM in DMSO
Synonyms:   MG-132, MG132, Z-LLL-CHO, MG 132

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Guo et al., MG132, a proteasome inhibitor, induces apoptosis in tumor cells. Asia Pac. J. Oncol. 2012, doi:10.1111/j.1743-7563.2012.01535.x
2. Shibata et al., Proteasome inhibitor MG-132 enhances the expression of interleukin-6 in human umbilical vein endothelial cells: Involvement of MAP/ERK kinase. Immunol. Cell Biol. 2002, 80, 226-230. Pubmed ID: 12067409
3. Yuan et al., Proteasome Inhibitor MG132 Induces Apoptosis and Inhibits Invasion of Human Malignant Pleural Mesothelioma Cells. Translational Oncol. 2008, 1(3), 129-140. Pubmed ID: 18795123

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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