Loading... Please wait...

Our Newsletter

MK-2206 | Akt1/Akt2/Akt3 inhibitor

  • MK-2206.jpg
  • MK-2206, 400x400px, png
Catalog #:

Product Description

MK-2206 is an orally bioavailable allosteric quinolinotriazolone inhibitor of the serine/threonine protein kinase Akt. It is selectively potent for Akt1, Akt2, and Akt3 at 5 nM, 12 nM, and 65 nM, respectively. MK-2206 inhibits auto-phosphorylation of Akt1/2 at position T308 and S473.

Combination studies with EGFR inhibitors (e.g. erlotinib and lapatinib) in cancer cell lines have shown synergistic effects in a dose-dependent manner [1], inhibiting both PI3K and Ras/Erk pathways. Recent studies indicate that breast cancer cell lines with PTEN loss and/or PIK3CA mutations were also more sensitive to MK-2206 [3], and that targeting eEF-2 kinase in conjunction with Akt can also enhance its antitumor effect [2].

Technical information:

Chemical Formula:   C25H21N5O.2HCl
CAS #:   1032350-13-2
Molecular Weight:   480.39
Purity:   >98%
Appearance:   Bright Yellow
Chemical Name:   8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one
Solubility:   Up to 20 mM in DMSO
Synonyms:   MK-2206, MK 2206, MK2206

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Hirai et al., MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther, 2010, 9(7), 1956. Pubmed ID: 20571069
2. Liu et al., Roles of eEF-2 kinase in cancer. Chin Med J 2012 125(16), 2908-2913 Pubmed ID: 22932089
3. Gonzalez-Angulo et al., Defining biomarkers to predict sensitivity to PI3K/Akt/mTOR pathway inhibitors in breast cancer. Cancer Treatment Rev 2012, in press.

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the MK-2206 | Akt1/Akt2/Akt3 inhibitor to your wish list.

You Recently Viewed...