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  • Nutlin-3a (200x200px)
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Catalog #:

Product Description

Nutlin-3a is an antagonist of murine double minute-2 (MDM2). By inhibiting MDM2-p53 interactions (IC50 = 90 nM), Nutlin-3a stabilizes p53 and induces cell cycle arrest and apoptosis in cells with functional p53. [1] Nutlin-3a induces autophagy and upregulation of AMPK in a p53-dependent manner in acute myelogenous leukemia cells (1-5 ?M). [2]

Technical information:

Chemical Formula:   C30H30Cl2N4O4
CAS #:   675576-98-4
Molecular Weight:   581.49
Purity:   > 98%
Appearance:   white
Chemical Name:   2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
Solubility:   Up to 100 mM in DMSO
Synonyms:   Nutlin-3a,(-)-Nutlin-3

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


1. Vassilev LT, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004; 303(5659):844-8 Pubmed ID: 14704432
2. Borthakur G, et al. MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation.PLoS One. 2015; 10(10):e0139254 Pubmed ID: 26440941

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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