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RU58841 | nonsteroidal anti-androgen

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  • RU58841, 400x400px, png
Price:
$169.00
Catalog #:
C7858-5
Quantity:


Product Description

RU58841 is a nonsteroidal anti-androgen with potency (IC50 = 100 nM, Ka = 1.1 nM) comparable to hydroxyflutamide. In competition studies, RU58841 suppresses dihydroxytestosterone (DHT) effects in PC3 cells with the wt AR in dose dependent manner, indicating antagonistic properties. [1]

Animal studies in the stumptailed macaque have shown that RU58841 has a dramatic effect on hair regrowth suggesting that it antagonizes testosterone-elicited follicular cell growth inhibition. [2]


Technical information:

Chemical Formula:   C17H18F3N3O3
CAS #:   154992-24-2
Molecular Weight:   369.34
Purity:   >98%
Appearance:   White
Chemical Name:   (Benzonitrile,4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)-)
Solubility:   Up to 22 mM in DMSO
Synonyms:   RU-58841, RU58841

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Pan et al., Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques. Endocrine 1998, 9(1), 39-43. Pubmed ID: 9798729
2. Obana et al., Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque. Endocrinology 1997, 138(1), 356-361. Pubmed ID: 8977424

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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