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SD-169 | p38 MAPK inhibitor

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Catalog #:

Product Description

SD169 is an indole-5-carboxamide, orally-available, ATP-competitive, a-selective p38 MAPK inhibitor that targets a wide variety of inflammatory cells, including neutrophils, monocytes, macrophages, B and CD4+ T cells, and endothelial cells. [1] Through interactions with Schwann cell and TNF activity, SD169 promotes axonal regeneration in peripheral nerves. [2]

SD169 has been shown to reduce myeloma-induced osteolytic bone lesions and restored bone mass by downregulating osteoclastogenesis and osteoblastogenesis in xenografted primary myeloma-SCID-hu or myeloma cell line-SCID mouse models. [3] SD169 was also shown downregulates pp38 in myeloma cells in vitro and in vivo.

In the diabetes therapeutic area, SD169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets. In studies using hyperglycemic NOD mice, SD169 treatment lowered blood glucose and improved glucose homeostasis. [4]

Technical information:

Chemical Formula:   C9H8N2O
CAS #:   1670-87-7
Molecular Weight:   160.17
Purity:   >98%
Appearance:   White
Chemical Name:   1H-indole-5-carboxamide
Solubility:   Up to 22 mM in DMSO
Synonyms:   SD-169, SD169

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Medicherla et al., p38 MAPK inhibition reduces diabetes-induced impairment of wound healing. Diabetes, Metab. Syndr. Obes. 2009, 2, 91-100. Pubmed ID: 21437122
2. Myers et al., Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp. Neurol. 2003, 184, 606-614. Pubmed ID: 14769353
3. Yang et al., Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma. Leukemia, 2012, 26, 2114-2123. Pubmed ID: 22425892
4. Medicherla et al., J. Pharmacol. Exp. Ther. 2006, 318(1), 99-107. Pubmed ID: 14769353

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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