Loading... Please wait...

Our Newsletter


SD-169 | p38 MAPK inhibitor

  • SD-169.jpg
  • SD-169, 400x400px, png
Price:
$59.00
Catalog #:
C7216-10
Quantity:


Product Description

SD169 is an indole-5-carboxamide, orally-available, ATP-competitive, a-selective p38 MAPK inhibitor that targets a wide variety of inflammatory cells, including neutrophils, monocytes, macrophages, B and CD4+ T cells, and endothelial cells. [1] Through interactions with Schwann cell and TNF activity, SD169 promotes axonal regeneration in peripheral nerves. [2]

SD169 has been shown to reduce myeloma-induced osteolytic bone lesions and restored bone mass by downregulating osteoclastogenesis and osteoblastogenesis in xenografted primary myeloma-SCID-hu or myeloma cell line-SCID mouse models. [3] SD169 was also shown downregulates pp38 in myeloma cells in vitro and in vivo.

In the diabetes therapeutic area, SD169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets. In studies using hyperglycemic NOD mice, SD169 treatment lowered blood glucose and improved glucose homeostasis. [4]


Technical information:

Chemical Formula:   C9H8N2O
CAS #:   1670-87-7
Molecular Weight:   160.17
Purity:   >98%
Appearance:   White
Chemical Name:   1H-indole-5-carboxamide
Solubility:   Up to 22 mM in DMSO
Synonyms:   SD-169, SD169

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Medicherla et al., p38 MAPK inhibition reduces diabetes-induced impairment of wound healing. Diabetes, Metab. Syndr. Obes. 2009, 2, 91-100. Pubmed ID: 21437122
2. Myers et al., Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp. Neurol. 2003, 184, 606-614. Pubmed ID: 14769353
3. Yang et al., Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma. Leukemia, 2012, 26, 2114-2123. Pubmed ID: 22425892
4. Medicherla et al., J. Pharmacol. Exp. Ther. 2006, 318(1), 99-107. Pubmed ID: 14769353

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the SD-169 | p38 MAPK inhibitor to your wish list.

You Recently Viewed...