Loading... Please wait...

Our Newsletter


Sorafenib | Raf1 inhibitor

  • Sorafenib.jpg
  • Sorafenib, 400x400px, png
Price:
$149.00
Catalog #:
C7672-5
Quantity:


Product Description

Sorafenib (BAY 43-9006) is biarylurea-based inhibitor of Raf1 (IC50, 6 nM) with additional activity against B-Raf, mVEGFR2, mPDGFRb (IC50, 22 nM, 15 nM, and 57 nM respectively), and related kinases. [1] In MDA-MB-231 breast cancer cells, sorafenib efficiently blocks activation of the MAPK pathway. Dose-dependent inhibition of basal MEK 1/2 and ERK 1/2 phosphorylation was observed at IC50s of 40 and 100 nM, respectively. [1]

In hepatocellular carcinoma cell lines, sorafenib inhibited cell proliferation in a dose-dependent manner with an IC50 of 6.3 uM in PLC/PRF/5 and 4.5 uM in HepG2 cells. [2] Flow cytometry studies indicated a decrease in G1 and increase of S phase after sorafenib treatment in HepG2 cells.


Technical information:

Chemical Formula:   C21H16ClF3N4O3
CAS #:   284461-73-0
Molecular Weight:   464.82
Purity:   >99%
Appearance:   White
Chemical Name:   4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
Solubility:   Up to 100mM in DMSO
Synonyms:   Sorafenib, Nexavar, sorafenibum, BAY-43-9006

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Wilhelm et al., BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004, 64, 7099-7109. Pubmed ID: 15466206
2. Liu et al., Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 2006, 66, 11851-11858. Pubmed ID: 17178882

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the Sorafenib | Raf1 inhibitor to your wish list.

You Recently Viewed...