Loading... Please wait...

Our Newsletter


Temozolomide | DNA alkylating agent

  • Temozolomide.jpg
  • Temozolomide, 400x400px, png
Price:
$49.00
Catalog #:
C8366-10
Quantity:


Product Description

Temozolomide is an highly orally-available, imidazotetrazine-based, monofunctional DNA alkylating agent. In vivo it spontaneously degrades and reacts with water to release a methyldiazonium cation which preferentially methylates DNA at N7 positions of guanine in guanine rich regions. The active agent also methylates N3 adenine and O6 guanine. [1]

Temozolomide, which enters the cerebrospinal fluid and does not require hepatic metabolism, demonstrates schedule-dependent antitumor activity against highly-resistant gliomas. [2] In Phase 1 clinical studies, temozolomide showed 100% p.o. bioavailability.

In L-1210 leukemia cells, temozolomide caused a dose-dependent accumulation of cells in the SL-G2-M phase. [3]


Technical information:

Chemical Formula:   C6H6N6O2
CAS #:   85622-93-1
Molecular Weight:   194.15
Purity:   >99%
Appearance:   White
Chemical Name:   4-methyl-5-oxo- 2,3,4,6,8-pentazabicyclo [4.3.0] nona-2,7,9-triene- 9-carboxamide
Solubility:   Up to 100 mM in DMSO
Synonyms:   Temozolomide, Temodar, Methazolastone

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Zhang et al., Temozolomide: mechanisms of action, repair and resistance. Curr. Mol. Pharmacol. 2012, 5, 102-114. Pubmed ID: 22122467
2. Friedman et al., Temozolomide and treatment of malignant glioma. Clin. Cancer Res. 2000, 6, 2585-2597. Pubmed ID: 10914698
3. Catapano et al., In vitro and in vivo methazolastone-induced DNA damage and repair in L-1210 leukemia sensitive and resistant to chloroethylnitrosoureas. Cancer Res. 1987, 47, 4884-4889. Pubmed ID: 3621181

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the Temozolomide | DNA alkylating agent to your wish list.

You Recently Viewed...