Loading... Please wait...

Our Newsletter

VX-702 | P38 MAPK inhibitor

  • VX-702.jpg
  • VX-702, 400x400px, png
Catalog #:

Product Description

VX-702 is an orally-available, aminopyridine-based, ATP-competitive inhibitor of p38 MAPK with a Kd of 3.7 nM and 17 nM at 10 uM for p38a and p38b, respectively. [1] In an ex vivo blood assay primed with LPS< VX-702 dose-dependently inhibited the production of IL-6, IL-1b, TNFa at IC50 of 59, 122, and 99 ng/mL, respectively. [2] VX-702 was found to be equivalent to prednisolone and methotrexate in a mouse collagen-induced arthritis model.

Clinical efficacy models plus transient suppression of inflammation biomarkers suggest that p38 MAPK inhibition by agents such as VX-702 may not be a viable approach to the treatment of chronic inflammation in RA. [3]

Technical information:

Chemical Formula:   C19H12F4N4O2
CAS #:   479543-46-9
Molecular Weight:   404.32
Purity:   >98%
Appearance:   White
Chemical Name:   1-(5-carbamoyl-6-(2,4-difluorophenyl)pyridin-2-yl)-1-(2,6-difluorophenyl)urea
Solubility:   Up to 100 mM in DMSO
Synonyms:   VX-702, VX702

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Goldstein et al., Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J. Med. Chem. 2010, 53, 2345-2353. Pubmed ID: 19950901
2. Ding, C., Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome. Curr. Opin. Invest. Drugs, 2006, 7(11), 1020-1025. Pubmed ID: 17117592
3. Damjanov et al., Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum., 2009, 60(5), 1232-1241. Pubmed ID: 19404957

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the VX-702 | P38 MAPK inhibitor to your wish list.

You Recently Viewed...