Loading... Please wait...

Our Newsletter


ABT-263 (Navitoclax) | Bcl-2 family inhibitor

  • ABT-263 (Navitoclax).jpg
  • ABT-263 (Navitoclax), 400x400px, png
Price:
$129.00
Catalog #:
C2263-5
Quantity:


Product Description

ABT-263 is an orally-available Bcl-2 family inhibitor with Ki values of < 1 nM for Bcl-2, Bcl-xL, and Bcl-w. ABT-263 disrupts key Bcl interactions with proteins such as Bim, inducing apoptosis. Despite being a Bad-like Bh3 mimetic, ABT-263 has been shown to possess cytotoxic activity and induce apoptosis based primarily on its Bcl-2 family inhibitory activity.

ABT-263 as a standalone agent has modest activity in lymphoma and myeloma xenografts, but is extremely effective in enhancing the efficacy of clinically relevant therapies such as rituxumab and bortezomib. (1)

In a panel of small cell lung cancer (SCLC) xenografts, including H146, H889, and H1963 models, ABT-263 displays excellent antitumor effects, leading to tumor regression. (2)


Technical information:

Chemical Formula:   C47H55ClF3N5O6S3
CAS #:   923654-51-6
Molecular Weight:   974.61
Purity:   > 98%
Appearance:   white
Chemical Name:   (R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide
Solubility:   Up to 100 mM in DMSO
Synonyms:   ABT-263, Navitoclax, ABT263, ABT 263

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Tse et al., ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor. Cancer Res. 2008, 68, 3421-3428. Pubmed ID: 18451170
2. Shoemaker et al., Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models. Clin. Cancer Res. 2008, 14, 3268-3277. Pubmed ID: 18519752

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Find Similar Products by Category

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the ABT-263 (Navitoclax) | Bcl-2 family inhibitor to your wish list.

You Recently Viewed...