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Ambrisentan | Endothelin receptor type A/ETa antagonist

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Price:
$89.00
Catalog #:
C2627-5
Quantity:


Product Description

Ambrisentan is a propanoic acid??based, orally-available, endothelin receptor type A-receptor antagonist for the once-daily treatment of pulmonary arterial hypertension (PAH). It has >4000-fold selectivity for the type A receptor over type B receptor. Studies indicate that Ambrisentan has a low potential for drug interactions and at therapeutic concentrations does not inhibit UDP-glucuronosyltransferases or CYPs, or induce MDR protein 2 or P-gp. (1)

In contrast with other similar therapies, Ambrisentan has been shown to have a lower potential for increase of serum-level concentrations of aminotransferases. (2)


Technical information:

Chemical Formula:   C22H22N2O4
CAS #:   177036-94-1
Molecular Weight:   378.42
Purity:   > 98%
Appearance:   white
Chemical Name:   (S)-2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid
Solubility:   Up to 100 mM in DMSO
Synonyms:   LU-208075, BSF-208075

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Frampton, JE., Ambrisentan. Am. J. Cardiovasc. Drugs 2011, 11(4), 215-226. Pubmed ID: 21623643
2. Galie et al., Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2. Circulation, 2008, 117, 3010-3019. Pubmed ID: 18506008

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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