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AT7519 | CDK inhibitor

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Price:
$109.00
Catalog #:
C2875-5
Quantity:


Product Description

AT7519 is a pyrazole-based multi-cyclin dependent kinase inhibitor with IC50 activity against CDK2, CDK5, and CDK9, of 47, 13, and
In a panel of 26 human tumor cell lines, AT7519 showed potent antiproliferative activity at 40-940 nM. 24h treatment of HCT116 cells showed phosphorylation inhibition of CDK1 substrate PP1a (T320) and CDK2 substrates Rb (T821) and NPM (T199). (2)


Technical information:

Chemical Formula:   C16H17Cl2N5O2
CAS #:   902135-91-5
Molecular Weight:   382.24
Purity:   > 98%
Appearance:   Light Yellow
Chemical Name:   4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide
Solubility:   Up to 25 mM in DMSO
Synonyms:   AT7519, AT 7519, AT-7519

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Santo et al., AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3b activation and RNA polymerase II inhibition. Oncogene, 2010, 29, 2325-2336. Pubmed ID: 20101221
2. Squires et al., Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. 2009, 8, 324-332. Pubmed ID: 19174555

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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