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BIX-01294 | G9a HMTase inhibitor

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Catalog #:

Product Description

BIX-01294 is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation of H3K9me2 in vitro. In its inhibition of the histone lysine methyltransferases, BIX-01294 does not compete with cofactor S-adenosyl-methionine. G9a HMTase regulates gene expression including one of the pluripotency genes Oct4.

It is reported that BIX-01294 enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors (Oct4, Klf4, Sox2 and c-Myc) were introduced to somatic cells for generation of induced pluripotent stem cells.

Technical information:

Chemical Formula:   C28H38N6O2
CAS #:   935693-62-2
Molecular Weight:   490.64
Purity:   >98%
Appearance:   Pale yellow solid
Chemical Name:   2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-
piperidinyl]-4-quinazolinamine trihydrochloride hydrate
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Kubicek, S. et al., Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase Mol. Cell. 3rd ed., 25, 473-481, (2007).
2. Shi, Y. et al. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2, 525-528, (2008).

Other Information:

Product Specification (pdf)
MSDS (pdf)

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