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CDDO (Bardoxolone) | anti-inflammatory

  • CDDO (Bardoxolone) (.png)
  • CDDO (Bardoxolone) (.jpg)
Price:
$169.00
Catalog #:
C2336-5
Quantity:


Product Description

CDDO is a synthetic oleanane triterpenoid. It is 400,000x more potent than natural product oleanolic acid in inhibiting cellular iNOS production when stimulated by IFN-gamma, TNF-alpha, and IL-1 [1]. The mechanism of action of CDDO remain elusive, despite its broad biological activities, including proliferation inhibition, apoptosis induction[2], and oxidative stress and inflammation suppression.

CDDO-methyl ester,an orally-available form of CDDO, is undergoing clinical development for the treatment of advanced chronic kidney disease (CKD) in type 2 diabetes mellitus patients.


Technical information:

Chemical Formula:   C31H41NO4
CAS #:   218600-44-3
Molecular Weight:   491.66
Purity:   > 98%
Appearance:   Brown
Chemical Name:   2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid
Solubility:   Up to 10 mM in DMSO
Synonyms:   CDDO, RTA-401, RTA401, Bardoxolone

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


Reference:

1. Sporn MB, et al. New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. J Nat Prod. 2011; 74(3):537-45. Pubmed ID: 21309592
2. Suh N, et al. A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Res. 1999; 59(2):336-41. Pubmed ID: 9927043

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.







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