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Daunorubicin hydrochloride | DNA intercating agent

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Price:
$69.00
Catalog #:
C3286-5
Quantity:


Product Description

Daunorubicin is an anthracycline drug used that killing cells by inhibiting DNA and RNA synthesis. It intercalates between base pairs and interacts with topoisomerase II, therefore inhibiting DNA replication and repair and RNA synthesis. Daunorubicin was initially isolated from Streptomyces peucetius.

In vitro, daunorubicin inhibits the proliferation of various tumor cells at micromolar level. (1) Clinically, it has been used in treating certain types of acute leukemia and neuroblastoma.


Technical information:

Chemical Formula:   C27H29NO10.HCl
CAS #:   23541-50-6
Molecular Weight:   563.98
Purity:   > 98%
Appearance:   orange red
Chemical Name:   (8S,10S)-8-acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione, monohydrochloride
Solubility:   Up to 100 mM in DMSO
Synonyms:   Daunorubicin hydrochloride

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Gewirtz DA, A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol. 1999;57(7):727-41. Pubmed ID: 10075079

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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