Loading... Please wait...

Our Newsletter


GW501516 | PPARδ agonist

  • GW501516.jpg
  • GW501516, 400x400px, png
Price:
$139.00
Catalog #:
C4950-2s
Quantity:


Product Description

GW501516 is a selective PPARd agonist with a Ki affinity of 1.1 nM in a human binding assay. In a cell-based transfection assay, GW501516 induces expression of GAL4-responsive reporter gene at an EC50 of 1.2 nM. At doses up to 1 uM, GW501516 does not promote adipocyte differentiation, bind to RXRa, or have activity toward other nuclear or non-nuclear receptors. (1) GW501516 incrases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux. (1)

GW501516 is also reported to be a PPARb agonist with anti-inflammatory activity and decreases IFN-g-induced upregulation of TNF-a and iNOS. Concurrently, GW501516 increase IL-6 mRNA expression. (2)


Technical information:

Chemical Formula:   C21H18F3NO3S2
CAS #:   317318-70-0
Molecular Weight:   453.5
Purity:   > 98%
Appearance:   white
Chemical Name:   2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)acetic acid
Solubility:   Up to 22 mM in DMSO
Synonyms:   GW501516, GW-501,516, GW1516, GSK-516, Endurobol

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Oliver et al., A selective peroxisome proliferator-activated receptor d agonist promotes reverse cholesterol transport. Proc. Nat'l. Acad. Sci. 2001, 98(9), 5306-5311. Pubmed ID: 11309497
2. Defaux et al., Effects of the PPAR-b agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination. J. Neuroinflammation, 2009, 6, 15-27. Pubmed ID: 19422681

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the GW501516 | PPARδ agonist to your wish list.

You Recently Viewed...