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IC-87114 | PI3Kδ inhibitor

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Price:
$89.00
Catalog #:
C4287-5
Quantity:


Product Description

IC-87114 is an ATP-competitive, purine-quinazoline-based inhibitor of PI3Kdelta with an IC50 of 0.5 uM. It is selective over other major isoforms of PI3K (PI3Ka = >100 uM; PI3Kb = 75 uM; PI3Kg = 29 uM) as well as a PIK-related kinases such as DNA-PK and mTOR. [1]
Studies with IC-87114 have assisted in showing that PI3Kdelta is responsible for fMLP-induced PIP3 generation in neutrophils and critical to chemotaxis, but not adhesion. Furthermore, inhibition of PI3Kdelta affects cell polarization and CD18 integrin-dependent chemotactic migration, but is less implicated in random movement. [1]


Technical information:

Chemical Formula:   C22H19N7O
CAS #:   371242-69-2
Molecular Weight:   397.43
Purity:   > 98%
Appearance:   White
Chemical Name:   2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
Solubility:   Up to 10 mM in DMSO
Synonyms:   IC-87114, IC87114, IC 87114

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Sadhu et al, Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J. Immunol. 2003, 170, 2647-2654. Pubmed ID: 12594293

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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