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INCB018424 | JAK1/2 inhibitor

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Catalog #:

Product Description

INCB018424 is an orally bioavailable, potent and selective inhibitor of JAK 1 and JAK2, currently in clinical trials to treat myelofibrosis. In enzyme assays it inhibited JAK1 (IC50=3.2 nM) and JAK2 (4.1 nM), and had selectivity >100 fold for a wide range of other kinases, including JAK3 (428 nM). It acts by blocking the JAK/STAT pathway, and has IC50 of 280nM in cytokine-stimulated whole blood assays.

Technical information:

Chemical Formula:   C17H18N6
CAS #:   941676-49-5
Molecular Weight:   306.37
Purity:   >98%
Appearance:   White solid
Chemical Name:   (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. A Quintas-Cardama et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 2010, 115(15), 3109-3117.
2. S Verstovsek et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N. Engl. J. Med. 2010, 363(12), 1117-1127.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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