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(+)-ITD-1 | TGF-β pathway inhibitor

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Price:
$219.00
Catalog #:
C4832-1s
Quantity:


Product Description

(+)-ITD-1 is a resolved enantiomer of ITD-1 that possesses a greater than 2-fold increase in TGF-β inhibition (~400 nM) and 1.3-fold increase in cardiogenesis compared to the racemic ITD-1. (+)-ITD-1 is largely responsible for TGF-β pathway-selective inhibition that inhibits TGF-β activity by selectively degrading the TGF-β2 receptor at the proteosome level. (+)-ITD-1 does not block the closely related Activin A signaling pathway. (+)-ITD-1 has been formulated as a salt to increase stability and improve water solubility (~0.1 mg/mL) for ease of handling. As a salt, ITD-1 is chemically and metabolically stable and can be used to study a wide range of biological questions in cellular processing and TGF-β signaling.


Technical information:

Chemical Formula:   C27H29NO3
CAS #:   N/A
Molecular Weight:   415.52
Purity:   >98%
Appearance:   Yellow solid
Chemical Name:   ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Willems E, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012;11(2):242-52. PMID: 22862949

Other Information:

Product Specification (pdf)
MSDS (pdf)

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