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Latanoprost | Prostaglandin F receptor (FP) agonist

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Price:
$139.00
Catalog #:
C5282-2s
Quantity:


Product Description

Latanoprost is a potent and selective agonist of Prostaglandin F receptor (FP). It activates FP, a G-protein coupled receptor (GPCR), with EC50 of 10 nM, and with at least 500-fold selectivty over other Prostaglandin receptors. (1) Upon activation, FP promotes the decrease of intraocular pressure and contraction of smooth muscle.

Clinically, Latanoprost (aka Xalatan(r)) is used as a topical ophthalmic solution for controlling the progression of glaucoma or ocular hypertension by increasing the outflow of aqueous fluid from the eyes, therefore reducing intraocular pressure. (2)


Technical information:

Chemical Formula:   C26H40O5
CAS #:   130209-82-4
Molecular Weight:   432.59
Purity:   > 98%
Appearance:   clear oil
Chemical Name:   (Z)-isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate
Solubility:   Up to 100 mM in DMSO
Synonyms:   latanoprost, Xalatan®

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Stjernschantz et al., From PGF2?-isopropyl ester to latanoprost: a review of the development of xalatan: the Proctor Lecture. Invest.Ophthalmol.Vis.Sci. 2001, 42(6):1134-45. Pubmed ID: 11328719
2. Camras CB et al., Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Latanoprost Study Groups. Ophthalmology. 1996, 103(11):1916-24. Pubmed ID: 8942890

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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