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LDN-193189 | BMP type I receptors ALK2/3 inhibitor

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Product Description

LDN193189 is a highly potent BMP inhibitor, prevents Smad1, Smad5, and Smad8 phosphorylation through inhibition of BMP type I receptors ALK2 (IC50=5nM) and ALK3 (IC50=30 nM). Its inhibitions against ALK4, ALK5, and ALK7 are weak (IC50 >500 nM). As BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms, LDN-193189 is used to reduce ectopic ossification in a mouse model.

Product Citation

Technical information:

Chemical Formula:   C25H22N6 C25H22N6
CAS #:   1062368-24-4
Molecular Weight:   406.48
Purity:   >98%
Appearance:   Yellow solid
Chemical Name:   4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Paul B Yu, et al. BMP type I receptor inhibition reduces heterotopic ossification. Nature Med. (2008) 14: 1363-1369.
2. Cuny GD, et al. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. (2008) 18(15):4388-92.
3. Paul B Yu, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature Chem Biol. (2008) 4: 33-41.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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