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LDN-57444 | UCH-L1inhibitor

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Catalog #:

Product Description

LDN-57444 is a specific inhibitor (Ki = 0.4 ?M) against Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), a member of deubiquitinating enzymes (DUBs). LDN-57444 increased proliferation of SH-SY5Y cells, a UCH-L1-expressing neuroblastoma line. [1]

As expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors, LDN-57444 is a useful tool for studying the roles of UCH-L1 in Alzheimer??s disease, Parkinson??s disease, and other neurological disorders. [2,3]

Technical information:

Chemical Formula:   C17H11Cl3N2O3
CAS #:   668467-91-2
Molecular Weight:   397.64
Purity:   > 98%
Appearance:   Yellow
Chemical Name:   1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)
Solubility:   Up to 25 mM in DMSO
Synonyms:   LDN-57444, LDN57444

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


1. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol. 2003; 10(9):837-46. Pubmed ID: 14522054
2. Cartier AE, et al. Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J Neurosci. 2009; 29(24):7857-68. Pubmed ID: 19535597
3. Zhang M, et al. Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1. J Neurochem. 2012; 120(6):1129-38. Pubmed ID: 22212137

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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