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LY294002 | PI3K inhibitor

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Product Description

LY294002 is a highly selective phosphatidylinositol 3-kinase (PI3K) inhibitor, with no inhibitory activities against EGF receptor kinase, MAP kinases, PKC, PI 4-kinase, S6 kinase and c-Src. Recent study also showed it inhibits of casein kinase II.

LY294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells. In regulation of murine ES cell self-renewal, LY294002 led to a reduction in the ability of LIF to maintain self-renewal via regulated expression of dominant negative delta-p85. It can also enhance the generation of mouse induced pluripotent stem cells.

Technical information:

Chemical Formula:   C19H17NO3
CAS #:   154447-36-6
Molecular Weight:   307.34
Purity:   >98%
Appearance:   White solid
Chemical Name:   2-morpholin-4-yl-8-phenylchromen-4-one
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Vlahos CJ et al. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 1994; 269(7):5241-8.
2. Paline NR et al. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem. 2004; 279(46):48063-70.
3. Chen T et al. Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell. 2011; 10(5):908-911

Other Information:

Product Specification (pdf)
MSDS (pdf)

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