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MLN-8237 | Autota A kinase inhibitor

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Price:
$109.00
Catalog #:
C6561-2s
Quantity:


Product Description

MLN-8237 is a second-generation, selective Aurora A kinase (AAK) inhibitor with an IC50 of 1 nM. MLN8237 shows 200-fold more selective activity against Aurora-A than related kinase Aurora-B. Inhibition of AAK by MLN-8237 induces cytotoxicity and cell arrest. Several completed as well as actively on-going phase I/II clinical trials evaluate MLN-8237 in advanced solid tumor as well as advanced hematological malignancies.


Technical information:

Chemical Formula:   C27H2OClFN4O4
CAS #:   1028486-01-2
Molecular Weight:   518.92
Purity:   >98%
Appearance:   White solid
Chemical Name:   4-((9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)-2-methoxybenzoic acid
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Gorgun G et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma. Blood. 2010; 115(25): 5202–5213.
2. Manfredi MG et al. Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays. Clin Cancer Res. 2011; 17(24):7614-24.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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