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NVP-BEZ235 | PI3K/mTOR inhibitor

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Price:
$79.00
Catalog #:
C2392-10
Quantity:


Product Description

BEZ235 (NVP-BEZ235) is a dual inhibitor of the PI3K and the downstream mammalian target of rapamycin (mTOR) by binding to the ATP-binding cleft of these enzymes. It inhibited the activation of the downstream effectors Akt, S6 ribosomal protein, and 4EBP1 in breast cancer cells. For Class I PI3K family, its biochemical IC50 is 4nM against p110α, 75nM against p110β, 7nM against p110σ, 5nM against p110γ. Quantification of S473-Akt and T308P-Akt levels by ELISA revealed that 50% reduction occurred at a compound concentration of 8.0 nM and 30 nM.


Technical information:

Chemical Formula:   C30H23N5O
CAS #:   915019-65-7
Molecular Weight:   469.54
Purity:   >98%
Appearance:   Pale white solid
Chemical Name:   2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo
[4,5-c]quinolin-1-yl)phenyl)propanenitrile
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Sauveur-Michel Maira et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol. Cancer Ther. 7: 1851 (2008).
2. Violeta Serra et al. NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations. Cancer Res. 68: 8022 (2008).

Other Information:

Product Specification (pdf)
MSDS (pdf)

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