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NVP-LDE225 | Smo inhibitor

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  • NVP-LDE225, 400x400px, png
Price:
$139.00
Catalog #:
C5332-2s
Quantity:


Product Description

LDE225 is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. It has been shown to potentially inhibit Hh-and Smo-dependent proliferation in vivo. It also induced the regression of preformed basaloid lesions with an IC50 of <150 nM and almost complete regression at 1.5 μM. Topical application of a 1% LDE225 solution to depilated skin of C57/BL6 mice completely inhibited hair growth during anagen phase as well as the expression of the Hh-pathway target genes (Gli1, Gli2, Sox9, and N-Myc) and partial inhibition was obtained when applying a 0.3% solution.


Technical information:

Chemical Formula:   C26H26F3N3O3
CAS #:   956697-53-3
Molecular Weight:   485.50
Purity:   >98%
Appearance:   White solid
Chemical Name:   N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Shifeng Pan et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med. Chem. Lett., 2010, 1 (3), pp 130–134.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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