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NVP-XAV939 | Wnt/β-catenin Inhibitor

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Price:
$159.00
Catalog #:
C9289-2s
Quantity:
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Product Description

XAV939 is a small molecule which selectively inhibits β-catenin-mediated transcription. It stimulates β-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex. Using a quantitative chemical proteomic approach, XAV939 was found to stabilize axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2 with IC50 of 11 nM and 4 nM.

Technical information:

Chemical Formula:   C14H11F3N2OS
CAS #:   284028-89-3
Molecular Weight:   312.31
Purity:   >98%
Appearance:   White solid
Chemical Name:   2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.

Reference:

1. Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling; Shih-Min A. Huang et al. Nature (2009) 461, 614-620
2. Hedin, L. et al. Forskolin effects on the cAMP system and steroidogenesis in the immature rat ovary. Mol Cell Endocrinol (1983) 33: 69-80.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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