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Ormetoprim | Dihydrofolate (DHF) reductase

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Catalog #:

Product Description

Ormetoprim is a diaminopyrimidine-based inhibitor of dihydrofolate reductase, the enzyme responsible for NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. (1) This inhibition results in the interference in folic acid production. In bacteria, Ormetoprim, weakly antibacterial by itself, can act as a potentiator by cotreatment with sulfadimethoxine, which in turn prevents the formation of folinic acid. (2)

Technical information:

Chemical Formula:   C14H18N4O2
CAS #:   6981-18-6
Molecular Weight:   274.32
Purity:   > 98%
Appearance:   white
Chemical Name:   2,4-Diamino-5-(6-methylveratryl)pyrimidine
Solubility:   Up to 100 mM in DMSO
Synonyms:   0

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Manchand et al., Syntheses of Antibacterial 2,4-Diamino-5 benzylpyrimidines. Ormetoprim and Trimethoprim. J. Org. Chem. 1992, 57, 3531-3535.
2. Boothe, D.M., Sulfonamides and Sulfonamide Combinations, Merck Manuals, March, 2012.

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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