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PS48 | PDK1 inhibitor

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Price:
$79.00
Catalog #:
C7748-5
Quantity:


Product Description

PS48 is an allosteric small molecule activator of phosphoinositide-dependent protein kinase 1 (PDK1). It binds to the HM/PIF binding pocket instead of the ATP-binding site. PS48 has been used to enhance reprogramming of neonatal human epidermal keratinocytes (NHEKs).


Technical information:

Chemical Formula:   C17H15ClO2
CAS #:   1180678-32-7
Molecular Weight:   286.75
Purity:   >98%
Appearance:   White solid
Chemical Name:   5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Hindie et al. Structure and allosteric effects of low-molecular- weight activators on the protein kinase PDK1. Nature Chem Biol. (2009) 5: 758-764.
2. Bobkova et al. Discovery of PDK1 Kinase Inhibitors with a novel mechanism of action by ultra-high throughput screening. J Biol Chem. (2010) 285: 18838-18846.
3. Zhu et al. Reprogramming of Human Primary Somatic Cells by Oct4 and Chemical Compounds. Cell Stem Cell. (2010) 7 (6)651-655.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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