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R406 | SYK inhibitor

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Price:
$129.00
Catalog #:
C7406-2s
Quantity:


Product Description

R406 is an orally available small molecule targeting spleen tyrosine kinase (SYK) inhibitor with IC50 ~40 nM. It can block Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 has shown efficacy in a number of animal models of immune disorders. R406’s pro-drug R788 (Fostamatinib) is currently in phase III clinical trials to treat rheumatoid arthritis.


Technical information:

Chemical Formula:   C22H23FN6O5
CAS #:   841290-80-0
Molecular Weight:   470.45
Purity:   >98%
Appearance:   Gray solid
Chemical Name:   6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Solubility:   Up to 20 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Braselmann S., et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006; 319(3):998-1008.
2. Sweeny DJ, Li W, Grossbard E, Lau DT. Contribution of gut bacteria to the metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey. Xenobiotica. 2010;40(6):415-23.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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