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Reversine | A3 adenosine receptor antagonist

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Product Description

Reversine is a 2,6-disubstituted purine derivative as a potent, selective A3 adenosine receptor antagonist. Reversine could induce differentiated myogenic-linage committed cells to become multipotent mesenchymal progenitor cells. Cultured myoblasts treated for four days with 5 µM reversine were dedifferentiated into confluent stem cell progenitors, that could then be induced by osteogenic or adipogenic medium to re-differentiate into bone or adipose precursors, respectively.

Technical information:

Chemical Formula:   C21H27N7O
CAS #:   656820-32-5
Molecular Weight:   393.45
Purity:   >98%
Appearance:   White solid
Chemical Name:   N6-cyclohexyl-N2-(4-morpholinophenyl)-1H-purine-2,6-diamine
Solubility:   Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Chen S, Zhang Q, Wu X, Schultz PG, Ding S. Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc.,(2004), 126(2):410–411.
2. Chen S, Takanashi S, Zhang Q, Xiong W, Zhu S, Peters EC, Ding S, Schultz PG. Reversine increases the plasticity of lineage-committed mammalian cells. Proc Natl Acad Sci U S A. (2007), 104(25):10482-7.
3. Perreira M, Jiang JK, Klutz AM, Gao ZG, Shainberg A, Lu C, Thomas CJ, Jacobson KA. "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. (2005), 48(15):4910-8.

Other Information:

Product Specification (pdf)
MSDS (pdf)

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